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3 Attention to potential drug interactions 5 Detection of secondary bacterial or fungal infections > The pathogenesis of COVID-19 is not yet well understood. There are two ways of getting into the cell: the receptor for the ACE2 enzyme or the transmembrane glycoprotein CD147 can serve as the virus receptor. The preferred route of entry of the virus into the cell has not been established. > At the end of 2019, a new coronavirus, SARS-CoV-2, was identified, which caused an outbreak of an acute respiratory infection called COVID-19 in Wuhan, China. Work uniform Since Behring and Kitasato reported the therapeutic effects of diphtheria antitoxin plasma in 1891, plasma therapy has become an important means of immunotherapy for acute infectious diseases.
This new infectious disease progresses rapidly in severely ill and critically ill patients. At an early stage, pathogens directly damage the target organs, and then lead to serious immunopathological damage.
Passive immune antibodies can effectively and directly neutralize pathogenic microorganisms, which reduces damage to target organs, and then blocks subsequent immunopathological damage.
During numerous global pandemic outbreaks, WHO has also emphasized that "convalescent plasma is one of the most recommended potential treatments and has been used in other epidemic outbreaks." Since the COVID -19 outbreak, initial mortality has been quite high due to the lack of specific and effective treatments.
Since the mortality rate is an important indicator that the public is concerned about, in order to avoid panic among the population, clinical treatment that can effectively reduce the mortality rate in critical cases is key.
As a provincial hospital in Zhejiang Province, we are responsible for treating patients from Hangzhou and critically ill patients from this province.
Our hospital has many potential convalescent plasma donors and critically ill patients who need plasma treatment.