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Recommendations on the principles of pathoanatomical diagnosis of HIV infection and the formation of a pathoanatomical diagnosis and encryption ) in accordance with ICD - 10 . General principles for postmortem diagnosis of HIV infection include : determination of HIV status; diagnosis of immunodeficiency at autopsy; diagnosis of opportunistic infections and other secondary diseases at autopsy; coordination of the final diagnosis with the specialists of the AIDS center; LKK (KILI) in medical facilities with a discrepancy in the diagnosis.

To make a diagnosis of HIV infection, you must: take into account clinical criteria, laboratory results (ELISA, IB, immunogram (data on the absolute and relative number of CD4, VL) to characterize the morphological manifestations of HIV infection.

In the absence or impossibility of correct interpretation of the ELISA / IB data, it is necessary to take into account the data on the detection of HIV RNA or DNA. a) the state of the lymphoid tissue - hyperplasia or lymphoid devastation of the lymph nodes, spleen b) the presence of HIV encephalitis or HIV encephalopathy c) weight loss - degree of exhaustion d) isolation of marker infections or tumors with an assessment of their role in the genesis of death The absence of signs of an immunodeficiency state allows us to speak of HIV infection in the acute or subclinical stage, in these cases it is more often considered as a concomitant disease in the presence of other diseases that can be associated with a fatal outcome (viral hepatitis, lobar pneumonia, influenza, etc.) When formulating a diagnosis and assessing cases of HIV infection with AIDS manifestation, it is necessary to take into account the presence of drug addiction, as well as chronic viral hepatitis (usually B + C or C).

It is chronic viral hepatitis in its terminal stage and characteristic complications (esophageal and gastric bleeding, phlegmon of the gastrointestinal tract with ascites-peritonitis, etc.) that have recently become the main diseases in cases where HIV infection is considered in heading combined, competing or concomitant disease.

If a patient has infectious and / or oncological diseases, including tuberculosis (for example, fibrous-cavernous, cirrhotic) before the detection of HIV infection, in the event of a death, the initial cause of death should usually be considered infectious or oncological diseases, and HIV infection may take the position of a comorbid or concomitant disease / condition (depending on the stage of HIV infection).

In the presence of conditions related to the list of AIDS markers, a mandatory indication in the diagnosis after the phase of HIV infection "AIDS" is required. All conditions related to AIDS require clear confirmation using appropriate methods and diagnosis of HIV infection. Without objective confirmation of an AIDS-indicator pathology at an autopsy (for example, if there is only a record of the attending physician in the medical records), AIDS as the cause of death is not included in the diagnosis. Taking into account international data, all B-cell non-Hodgkin's lymphomas should also be classified as AIDS-defining diseases . To establish the concept of “pronounced immunodeficiency” and classify manifestations[1] of tuberculosis and other infectious diseases as AIDS, the laboratory criterion should be the CD4 count 25 (or body weight >75 kg).