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recommended that physicians responsible for the care of HIV-infected individuals obtain written “informed consent” from the patient, certified by the attending physician, before prescribing ART (see Appendix D2) [89] (2A) Comments: The signing of the "Informed Consent for ART" is the logical conclusion of the preparation (including psychological) of the patient for ART and includes a mandatory discussion with the patient of all the provisions of the informed consent.
recommended that clinicians responsible for the care of HIV-infected individuals should test for genotypic resistance prior to initiating ART, preferably as soon as an HIV diagnosis is made; or before starting ART [113] (5S): all patients in regions with a prevalence of resistance greater than 10% who are at high risk of primary NNRTI resistance due to widespread use of
Attention should be paid to the anamnesis of Hydrochloride) (Tetracycline General - Buy Tetracycline health 500mg life online and illness, a thorough physical examination and the necessary laboratory and instrumental studies. recommended that doctors responsible for monitoring HIV-infected people carry out the following diagnostic measures to make a decision on the choice of ARVs: determination of the level of creatinine in the blood serum (calculation of the glomerular filtration rate) – when choosing TDF** [37,48,49,50,117] (2A); study of the HLA B*5701 allele - when choosing ABC** [37,118,119] (2B); study of the level of hemoglobin and neutrophils - when choosing ZDV[OAS1] [EC2] [EC3] **, FAZT ** [37,120,121] (2B); determination of the number of CD4+ lymphocytes - when choosing EFV**, NVP**, RPV [37,122,123] (4Ń); study of the level of transaminases - when choosing ABC **, NVP **; EFV** [37,124] (5C); study of the level of bilirubin and its fractions - when choosing ATV ** [37,125] (4C); lipid profiling – when choosing PI and EFV** [37,126] (4C); detection of osteopenia or its high risk - when choosing TDF** [37,48,49,50] (2B). recommended that physicians responsible for the care of HIV-infected patients use the less toxic and most convenient treatment regimens in the form of fixed-dose combinations when prescribing first-line ART (starting ART) [37,127] (2A).
not recommended that physicians responsible for the care of HIV-infected patients include first-generation NNRTI ART drugs in the starting regimen without first conducting a resistance test in cases where there is a high risk of NNRTI resistance as a result of the use of this group of drugs in PMTCT [37,96,104,128,129] (2B).