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Clinical guidelines HIV infection in adults ICD 10: B 20, B 21, B 22, B 23, B 24, Z 21 Year of approval (revision frequency): 2020 ID: KR79/1 URL Professional associations National Association of Specialists in the Prevention, Diagnosis and Treatment of HIV Infection National Virological Association Approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation Table of contents Keywords List of abbreviations Terms and Definitions 1. short information 2. Diagnostics 3. Treatment 4. Rehabilitation 5. Prevention 6. Additional information affecting the course and outcome of the disease Criteria for assessing the quality of medical care Bibliography Annex A1. Methodology for the development of clinical guidelines Annex A3.

List of abbreviations ALT - alanine aminotransferase ARVP - antiretroviral drugs ART – antiretroviral therapy AST - aspartate aminotransferase HIV - human immunodeficiency virus VN - viral load - the number of copies of HIV RNA in 1 ml of biosubstrate WHO - World Health Organization IRIS - Immune System Recovery Inflammatory Syndrome DN - dispensary observation DNA - deoxyribonucleic acid GIT - gastrointestinal tract IB - immunoblotting II - HIV integrase inhibitors BMI - body mass index PIs - HIV protease inhibitors PI / r – Ritonavir-boosted HIV protease inhibitors IS - immune status IS - fusion inhibitors (fusions) IRI - immunoregulatory index ELISA - enzyme immunoassay ICA - immunochromatographic analysis ICLA - immunochemiluminescent assay CT - computed tomography PLHIV – people living with HIV ICD-10 - International Classification of Diseases and Related Health Problems, 10th revision MRI - magnetic resonance imaging MO - medical organization NRTIs - nucleo(t)ide inhibitors of HIV reverse transcriptase NNRTIs – non-nucleoside HIV reverse transcriptase inhibitors CBC - complete blood count OAM - general urinalysis OGK - chest organs PGL - persistent generalized lymphadenopathy PEP - post-exposure prophylaxis PCR - polymerase chain reaction PCP - pneumocystis pneumonia RK - Russian classification of HIV infection RNA - ribonucleic acid SK - Kaposi's sarcoma GFR - glomerular filtration rate AIDS - Acquired Immune Deficiency Syndrome CCC - cardiovascular system CVD - cardiovascular disease UNRZ - unique register record number Ultrasound - ultrasonography F-AZT - Phosphaside FDC - fixed dose combination CHBV - chronic viral hepatitis B CHC - chronic viral hepatitis C CKD - chronic kidney disease CP - chemoprophylaxis CRF - chronic renal failure CMV - cytomegalovirus infection CNS - central nervous system ECG - electrocardiography 3TC - Lamivudine ABC - Abacavir ABC / 3TC - Abacavir + Lamivudine (PKD) ABC / ZDV / 3TC - Abacavir + Zidovudine + Lamivudine (PKD) ATV - Atazanavir BIC / FTC / TAF - Bictegravir + Tenofovir Alafenamide + Emtricitabine (FKD) CD - Cluster of Differentiation CD4 - CD4+ lymphocytes (T-lymphocytes with CD4 + receptor ) CD8 - CD8+ lymphocytes (T-lymphocytes with CD8 + receptor ) COBI - Cobicistat d4T - Stavudine ddI - Didanosine DHHS - US Department of Health and Human Services DOR - Doravirin DOR / TDF / 3TC - Doravirine + Lamivudine + Tenofovir (PKD) DRV - Darunavir DTG - Dolutegravir EFV - Efavirenz ETR - Etravirine ESV - Elsulfavirin EVG / C / FTC / TAF - Cobicistat + Tenofovir Alafenamide + Elvitegravir + Emtricitabine (PKD) FPV - Fosamprenavir FTC - Emtricitabine HLA - human leukocyte antigen HLA-B * 5701 - allele 5701 locus B of the human major histocompatibility complex IGRA - Interferon gamma release assay LPV / RTV - Lopinavir + Ritonavir (PKD) MVC - Maraviroc NVP - Nevirapine RAL - Raltegravir RPV – Rilpivirine RPV / TDF / FTC - Rilpivirine + Tenofovir + Emtricitabine (PKD) RTV, r - Ritonavir SQV - Saquinavir TAF - Tenofovir Alafenamide TDF – Tenofovir** (active substance Tenofovir disoproxil fumarate) ZDV – Zidovudine Terms and Definitions Antiretroviral therapy (ART) is an etiotropic therapy for infection caused by the human immunodeficiency virus (HIV infection), which allows to achieve a controlled course of the disease, is prescribed for life and is based on the simultaneous use of several antiretroviral drugs that act at different stages of the HIV life cycle.

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