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According to the results of clinical laboratory and instrumental studies, the state of the main organs and systems of the body (CNS, hematopoiesis, kidneys, liver, lungs, CVS), the presence of concomitant and secondary infections (CVH B and C, tuberculosis, toxoplasmosis) and conditions (pregnancy), as well as viral replication activity (VN) and severity of immunosuppression (CD4 level). The scope of required research is presented in Section 2.3.
recommended that physicians responsible for the care of HIV-infected patients prepare the patient psychologically before starting ART [89,90,91] (2A) Comments: Treatment is conducted on a voluntary basis and involves the active participation of the patient, therefore, the most important component of the success of ART is the psychological preparation of the patient, an integral part of which is counseling on adherence to treatment, its expected effectiveness, contraindications and possible complications of the planned therapy. Women of childbearing age are informed about the possible impact of the treatment on the course of pregnancy and fetal development. recommended that physicians responsible for the care of HIV-infected individuals obtain written “informed consent” from the patient, certified by the attending physician, before prescribing ART (see Appendix D2) [89] (2A) Comments: The signing of the "Informed Consent for ART" is the logical conclusion of the preparation (including psychological) of the patient for ART and includes a mandatory Cytoxan online 50mg discussion - Buy (Cyclophosphamide) Cancer with the patient of all the provisions of the informed consent. recommended that clinicians responsible for Buy Cytoxan the (Cyclophosphamide) 50mg online - Cancer care of HIV-infected individuals should test for genotypic resistance prior to initiating ART, preferably as soon as an HIV diagnosis is made; or before starting ART [113] (5S): all patients in regions with a prevalence of resistance greater than 10% who are at high risk of primary NNRTI resistance due to widespread use of this group of drugs in the region Characteristics of ARVs and (Cyclophosphamide) online ART Buy 50mg Cancer Cytoxan - regimens are presented in Appendix D1.
recommended that physicians responsible for monitoring HIV-infected patients choose the optimal ART regimen for a given patient, taking into account possible contraindications to prescribing individual ARVs and risk factors for their use [3,4,37,97,114,115,116] (2A) .
Comments: To identify possible contraindications to prescribing a specific ARV, you should carefully study the attached instructions before prescribing it.
Attention should be paid to the anamnesis of life and illness, a thorough physical examination and the necessary laboratory and instrumental studies.
recommended that doctors responsible for monitoring HIV-infected people carry out the following diagnostic measures to make a decision on the choice of ARVs: determination of the level of creatinine in the blood serum (calculation of the glomerular filtration rate) – when choosing TDF** [37,48,49,50,117] (2A); study of the HLA B*5701 allele - when choosing ABC** [37,118,119] (2B); study of the level of hemoglobin and neutrophils - when choosing ZDV[OAS1] [EC2] [EC3] **, FAZT ** [37,120,121] (2B); determination of the number of CD4+ lymphocytes - when choosing EFV**, NVP**, RPV [37,122,123] (4Ń); study of the level of transaminases - when choosing ABC **, NVP **; EFV** [37,124] (5C); study of the level of bilirubin and its fractions - when choosing ATV ** [37,125] (4C); lipid profiling – when choosing PI and EFV** [37,126] (4C); detection of osteopenia or its high risk - when choosing TDF** [37,48,49,50] (2B).