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7. Features of the course and morphological diagnosis of cytomegalovirus infection in HIV infection.
B20.2 The detection of characteristically transformed cells during histological examination with high accuracy indicates the replicative form of this infection. As an additional diagnostic method, an immunohistochemical reaction can be used, which reveals the affected cells before the development of cytomegalic transformation. Around the cells containing viral inclusions, lymphohistiocytic and eosinophilic infiltration is naturally determined. Cytomegalic lesions are detected in the adrenal glands, kidneys, lungs, liver, brain, retina, thyroid gland and other organs, as well as in the mucous membranes of the gastrointestinal tract and the endothelium of various organs. 8. Features of the course and morphological diagnosis of herpes virus infection in HIV infection.
B20.3 In pathoanatomical practice, focal necrotic encephalitis occurs.
Histological examination determined focal necrosis, with varying degrees of severity of glia proliferation and vasculitis. The most characteristic is the appearance of cells with hyperchromic nuclei, sometimes clear intranuclear basophilic inclusions are determined.
Aphthous lesions of the mucous membranes also occur. Immunohistochemical study of lesions caused by the herpes simplex virus shows the presence of two fundamental forms - with the expression of the virus antigen in the cells of the reticuloendothelial system without affecting the parenchymal cells and the combined virus infection of the cells of the reticuloendothelial system and parenchymal cells.
In the latter case, there are distinct morphological signs of herpes virus tissue damage, often in the form of small "necrotic nodules".
Kaposi 's sarcoma ( B21.0 ) associated with herpesvirus type 8 in young patients is a classic HIV/AIDS-associated pathology.
Primary localization on the skin, as well as the mucous membranes of the oral cavity in the form of a red-brown vascular papule or nodular formation. Possible metastasis to the lungs, lymph nodes, organs of the gastrointestinal tract. There have been cases of KS with a primary lesion of the mucous membranes. There are stages of spots, papules and nodular lesions. Patients with HIV infection with the development of KS (the so-called epidemic type of KS) are characterized by young age and the presence, in addition to skin elements, of visceral manifestations. Cerebral lymphoma (B.21.2) is an isolated extranodular B-cell tumor.
The development of generalized forms of damage is characteristic, with the involvement of all groups of lymph nodes and various internal organs (spleen, liver, lungs, intestines, etc.) in the process. Recently, there has been an increase in the background of HIV infection and many Buy Stendra (Avanafil) 100mg, 50mg online - Erectile Dysfunction other tumors, including squamous cell carcinoma of the cervix, caused by the human papillomavirus. Recommendations on the principles of pathoanatomical diagnosis of HIV infection and the formation of a pathoanatomical diagnosis and encryption ) in accordance with ICD - 10 . General principles for postmortem diagnosis of HIV infection include : determination of HIV status; diagnosis of immunodeficiency at autopsy; diagnosis of opportunistic infections and other secondary diseases Erectile (Avanafil) Buy 100mg, Stendra 50mg online Dysfunction at - autopsy; coordination of the final diagnosis with the specialists of the AIDS center; LKK (KILI) in medical facilities with a discrepancy in the diagnosis.