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In the stage of acute infection, a transient decrease in CD4 levels is often noted. Stage 2B - acute HIV infection with secondary diseases . In 10–15% of cases, patients with acute HIV infection against the background of a pronounced decrease in the level of CD4 and the resulting immunodeficiency develop secondary diseases of various etiologies (tonsillitis, bacterial pneumonia, candidiasis, herpes infection, etc.).

These manifestations, as a rule, are mild, short-lived, respond well to therapy, but can be severe (candida esophagitis, pneumocystis pneumonia) and, in rare cases, be fatal.

The duration of clinical manifestations of acute HIV infection varies from several days to several months, but is usually 2-3 weeks. An exception is lymph node enlargement, which may persist throughout the disease. Clinical manifestations of acute HIV infection may recur. In the vast majority of patients, the stage of primary manifestations of (Diclofenac) 50mg Voveran - online HIV Pain Buy Relief infection passes into the subclinical stage, but in some cases it can pass into the stage of secondary diseases.

Stage 3 - subclinical - is characterized by a slow progression of immunodeficiency, compensated by a modification of the immune response and excessive reproduction of CD4. Antibodies to HIV are found in the blood; the rate of virus replication, in comparison with the stage of primary manifestations, slows down. The only clinical manifestation of the disease is lymph node enlargement, which is usually generalized (persistent generalized lymphadenopathy,

The duration of the subclinical stage can vary from 2–3 to 20 years or more, with an average of 6–7 years. During this period, there is a gradual decrease in the number of CD4 with an average rate of 50-70 µl -1 per year. HIV replication continues, which is accompanied by the death of CD4 and the depletion of their population.

This leads to the development of secondary (opportunistic) infectious and / or oncological diseases against the background of immunodeficiency. Clinical manifestations of opportunistic diseases, along with PGL, which persists in most patients with HIV infection, determine the clinical picture of the stage of secondary diseases.

Depending on the severity of secondary diseases, there are: Stage 4A (usually develops 6-7 years after infection).

It is characterized by bacterial, fungal and viral lesions of the mucous membranes and skin, inflammatory diseases of the upper respiratory tract. Typically, stage 4A develops in patients with a CD4 count of about 350 µl Buy Voveran (Diclofenac) 50mg online - -1 Pain Relief .

Stage 4B (usually 7-10 years after infection) - skin lesions are deeper and tend to be protracted.