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The stage of primary manifestations can proceed in several forms. Stage 2A - asymptomatic , when there are no clinical manifestations of HIV infection or opportunistic diseases developing against the background of immunodeficiency.

The body's response to the introduction of HIV is manifested in this case only by the production of antibodies. Stage 2B - Acute HIV infection without secondary disease may present with a variety of clinical symptoms.

Most often, this is an increase in lymph nodes, fever, pharyngitis, rashes (urticarial, papular, petechial) on the skin and mucous membranes. There may be an increase in the liver, spleen, the appearance of diarrhea. Sometimes aseptic meningitis develops, which is characterized by a meningeal syndrome with an increase in CSF pressure in the absence of its visual and cytological changes.

Due to the fact that the clinical picture of acute HIV infection often resembles measles, rubella, infectious mononucleosis, it is called "mononucleosis-like syndrome", "rubella-like syndrome". The similarity with infectious mononucleosis enhances the appearance in the blood of patients with acute HIV infection of wide plasma lymphocytes (mononuclear cells).

A mononucleosis-like or rubella-like picture is observed in 15–30% of patients with acute HIV infection; most develop 1-2 of the above symptoms in any combination.

In some patients with HIV infection, autoimmune lesions may Buy occur Himcolin 30g online - Herbals. In general, the acute Buy stage Himcolin 30g online - Herbals of HIV infection is recorded in 50–90% of infected individuals in the first 3 months.

The onset of the acute infection period usually precedes seroconversion, therefore, when the first clinical symptoms appear, antibodies to HIV may not be detected in the patient's blood serum.

In the stage of acute infection, a transient decrease in CD4 levels is often noted.

Stage 2B - acute HIV infection with secondary diseases . In 10–15% of cases, patients with acute HIV infection against the background of a pronounced decrease in the level of CD4 and the resulting immunodeficiency develop secondary diseases of various etiologies (tonsillitis, bacterial pneumonia, candidiasis, herpes infection, etc.).

These manifestations, as a rule, are mild, short-lived, respond well to therapy, but can be severe (candida esophagitis, pneumocystis pneumonia) and, in rare cases, be fatal. The duration of clinical manifestations of acute HIV infection varies from several days to several months, but is usually 2-3 weeks. An exception is lymph node enlargement, which may persist throughout the disease.

Clinical manifestations of acute HIV infection may recur.

In the vast majority of patients, the stage of primary manifestations of HIV infection passes into the subclinical stage, but in some cases it can pass into the stage of secondary diseases.

Stage 3 - subclinical - is characterized by a slow progression of immunodeficiency, compensated by a modification of the immune response and excessive reproduction of CD4. Antibodies to HIV are found in the blood; the rate of virus replication, in comparison with the stage of primary manifestations, slows down. The only clinical manifestation of the disease is lymph node enlargement, which is usually generalized (persistent generalized lymphadenopathy, PGL), but may be absent. There may be (more often in children) such laboratory changes as anemia, thrombocytopenia, including those leading to clinical manifestations of impaired hemostasis.