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> Prior to 2002, coronaviruses were thought to cause only mild respiratory infections in humans, as well as gastroenteritis in newborns.

In 2002–2003, there was an outbreak of SARS-CoV-1 infection with the development of SARS. In 2012, there was an outbreak of MERS-CoV infection (periodic outbreaks of infection caused by this type of coronavirus are still being recorded). - Life-threatening course: > Severity of the clinical picture: 49% mortality in critically ill patients (5) Move the waste to the medical waste temporary storage facility along the designated route at the designated time and store the waste separately at the designated location; • Critical - 5% (1) Visible contaminants should be completely removed before disinfection and treated in accordance with the technological regulations for the

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of spilled blood and biological fluids; darunavir / cobicistat In combination with drugs associated with the metabolism of CYP 3 A and / or CYP 2 D 6, the concentration of the combined drug in plasma may increase. See lopinavir/ritonavir See lopinavir/ritonavir > Treatment of comorbid diseases, conditions, complications is carried out in accordance with clinical guidelines for these diseases, conditions, complications.

> Most severe forms in elderly patients >65 years of age. (4) Al CT system for COVID -19 can help reduce workload, identify probable cases quickly, and avoid misdiagnosis. Concentration range and breakpoints of common TDM drugs for COVID patients - If the patient is not suitable for long-term mechanical ventilation, i.e. If the patient fails to achieve the expected results, an ECMO replacement should be performed immediately. When one of the following conditions occurs, ECMO replacement should be considered.

It is recommended to take tests for C -reactive protein, procalcitonin, ferritin, D -dimer, total and subpopulations of lymphocytes, interleukin s IL -4, IL - 6, IL - 10, TNF - ?

, INF -y and other indicators of inflammation and immune status that can help assess the clinical course of the disease, alert about severe and critical conditions, and also serve as the basis for the formation of treatment strategies . The prognosis of the development of the disease is difficult due to the incomparability of national statistical data - a variety of anti-epidemic measures, methods Poland • Light - 81% • normal body temperature for 3 days (after discharge from the hospital, the patient starts work no earlier than 7 days after the temperature returns to normal); RESEARCH DIRECTIONS • carrying out disinfection measures with strict observance of the recommended technology; Note.

It is impossible to delay the start of mechanical ventilation due to the risk of developing severe uncontrolled pneumonia and severe hypoxemia - constant monitoring and assessment of the state of breathing and gas exchange is necessary.