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prednisolone 1 mg/kg is prescribed, followed by a dose reduction, as well as oxygen therapy.
recommended to carry out primary prevention (preventive treatment) of toxoplasmosis with a CD4 count 200 µl-1 and undetectable HIV-VL for 3 months. Treatment of toxoplasmosis (the cerebral form is more often diagnosed) is recommended at the slightest suspicion of a disease, without waiting for the results of the examination. [108, 232, 233] (5C): Choice regimen: Co-trimoxazole [Sulfamethoxazole+Trimethoprim]**, 25/5 mg [OAS4] [EC5]/kg po. Or Co-trimoxazole [Sulfamethoxazole+Trimethoprim]** IV drip Starting dose was 50/10 mg/kg/day or 75/15 mg/kg/day in two divided doses until clinical improvement (usually 3-5 days), then 37.5 / 7.5 mg / kg / day per day for at least 6 weeks.
(until elimination of at least 75% of lesions on MRI of the brain). After the end of the treatment course, secondary prevention of toxoplasmosis is carried out according to the scheme of trimethoprim 160/800 mg 2 times a day until CD4 > 200 ?l -1 and undetectable HIV-VL for 6 months. Chemoprophylaxis of cerebral toxoplasmosis of the brain is prescribed according to immunological indications with a CD4 count 200 ?l -1 within 3 months.
All patients with HIV infection and confirmed Kaposi's sarcoma are recommended to receive ART, which is the main method to prevent disease progression and achieve clinical improvement. In severe form of Kaposi's sarcoma, which occurs with the involvement of internal organs in the pathological process, doxorubicin ** or #daunorubicin ** (liposomal) 40 mg / m 2 every two weeks with individual dose selection is recommended.
Recommended for all HIV-infected patients with candidal stomatitis: Choice regimen: Fluconazole** 200 mg orally on the first day, then 100 mg orally 1 time per day until clinical effect is achieved (7-14 days). Alternative schemes: Itraconazole 100 mg twice a day.
[3,4,5,108,238,239] (5C) #Posaconazole 400 mg twice daily for the first 1–3 days of treatment, then 400 mg daily [3,4,5,108,239,240,242] (3A) #Voriconazole** 200mg PO BID or IV loading dose 6mg/kg BID, maintenance dose 3-4mg/kg BID.
[108] (5C) Caspofungin** 50 mg daily intravenously.
[108] (5S) Micafungin** 150 mg intravenously daily.
[108] (5S) Amphotericin B** 0.3 mg/kg per day intravenously.
[3,4,5,108] (5C) Prevention of relapses Fluconazole** 100–200 mg orally daily or 200 mg 3 times a week until the CD4 count > 200 µl - 1 [3, 4, 5, 108, 243] (5C).
Recommended for all HIV-infected patients with candidal esophagitis: Treatment.
Selection scheme Fluconazole** 400 mg on the first day, then 200 mg per day orally for 2–3 weeks [3,4,5,108] (5C). Alternative schemes Itraconazole 100–200 mg twice daily [108] (5C) #Posaconazole** 400 mg twice daily for the first 3 days of treatment, then 400 mg daily.
[108, 240] (5C) Voriconazole** 200 mg PO BID or IV loading dose 6 mg/kg BID, maintenance dose 3–4 mg/kg BID [108] (5C) Caspofungin** 50 mg IV 1 time per day [108] (5Ñ) Micafungin** 150 mg IV once a day. [108, 241] (2A) #Amphotericin B** 0.3–0.7 mg/kg per day IV drip, then the dose is selected individually depending on the severity of the condition [108] (5C) #Amphotericin B [liposomal] 4mg/kg daily i.v. drip [108] (5C) It is recommended to carry out prophylaxis (preventive treatment) and treatment of non-tuberculous mycobacterioses (M.