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Preparations should be in a place accessible to the staff of the institution, including in the evening and at night, weekends and holidays. The function of prescribing drugs in these cases is assigned to the doctor on duty. Dispensary observation Dispensary observation is a prerequisite for ART.

All patients diagnosed with HIV infection who applied to specialized healthcare institutions (authorized medical organization), after consultation, clinical examination with the establishment of a clinical diagnosis, are subject to dispensary registration and a comprehensive examination, as well as preparation for ART. Dispensary observation of patients with HIV infection is carried out by a specially trained infectious disease doctor of the center for the prevention and control of AIDS and infectious diseases or infectious disease doctors of other medical institutions (federal, regional and municipal subordination) authorized by the state executive authority in the field of healthcare, who have been trained to work with patients with HIV infection, when interacting with specialists from the AIDS Center.

The tasks of the examination when registering for a dispensary for HIV infection include: confirmation of the diagnosis of HIV infection; determination of the clinical stage and phase of HIV infection; identification of indications for ART; identification of indications for chemoprophylaxis of secondary diseases; diagnostics, treatment and prevention of secondary diseases; identification of concomitant diseases (including those associated with HIV infection), determination of their severity and the need for further examination and treatment; counseling, establishing contact and psychosocial adaptation of the patient.

The objectives of the clinical and laboratory examination conducted against the background of ART are: assessment of the course of HIV infection; evaluation of the effectiveness of the therapy; assessment of the safety of the therapy; assessment of the completeness of the therapy; identification of secondary and concomitant diseases, indications for their prevention and treatment, assessment of their course; assessment of the patient's adherence to therapy and identification of factors that violate it. Planned diagnostic measures during dispensary observation of patients with HIV infection before and during ART - see the section "Diagnostics of diseases", subsections 3-5. recommended that doctors responsible for monitoring HIV-infected people carry out planned diagnostic and advisory activities during the course of ART in order to identify its effectiveness and safety, as well as adherence to treatment (Table 10) [3, 4, 5, 37, 202] (2B).

Table 10 Timing of routine examinations in patients on ART [150, 161, 203–209] (3B).

Timing from start of ART Inspection, consultation Research 1 month after starting ART - anamnesis; - physical examination; - ART counseling; - ART adherence assessment - VN study (quantitative determination of human immunodeficiency virus RNA HIV-1 in blood plasma by the method PCR) [131]; - general (clinical) blood test [150]; - determination of the activity of ALT, AST in the blood, - blood creatinine test 2 months after starting ART - anamnesis; - physical examination; - ART counseling; - ART adherence assessment - study of VL (carried out in the case if during the first month of treatment VL decreased by less than 10 times) 3 months after starting ART - anamnesis; - physical examination; - ART counseling; - ART adherence assessment - study of VL, CD4; - general (clinical) blood test; - determination of ALT activity, creatinine; - general (clinical) urinalysis Then every 3 months until VL drops below detection level -1 and CD4 growth ?500 µl - anamnesis; - physical examination; - ART counseling; - ART adherence assessment - study of VL, CD4; - general (clinical) blood test; - determination of the activity of ALT, AST in the blood, - study of the level of creatinine in the blood; - general (clinical) urinalysis AST Comment: if 1.5 years after the start of ART, the patient has no clinical manifestations of secondary diseases for 6 months or more, and in the last two studies conducted at least 3 months apart, the CD4 count is ?500 ?l -1 and VL is below the level determination, planned visits can be carried out at intervals of 6 months.